Platelet shortages come to an end with this new discovery

New Delhi, May 2017:

A new discovery may be the key to stopping shortages of these vital blood-clotting cells that can represent the difference between life and death, says a study.

The finding from the University of Virginia School of Medicine also could offer big benefits for premature babies, opening the door to new treatments for a serious condition called neonatal thrombocytopenia that affects up to 30 percent of babies in neonatal intensive care units.

The researchers identified a "master switch" that they may be able to manipulate to overcome the obstacles that have prevented doctors from producing platelets in large quantities outside the body.

"The platelet supply is limited and the demand is growing," said researcher Adam Goldfarb. "The quantities we can produce outside the body are very, very small, and the inability to scale up right now is a major roadblock. We think that our understanding of this pathway is actually a critical step toward fixing that problem."

Scientists also may be able to use this master switch to battle neonatal thrombocytopenia, a condition that complicates the care of babies who are already at great risk. "It turns out in premature infants and newborns that [the platelet] reserve is compromised. They are less capable of responding to distress and the demand for increased platelet production," Goldfarb said. "A goodly percentage of those babies, these tiny little babies, require platelet transfusions to keep their platelets up."

The switch discovered by Goldfarb's team controls whether the bone marrow produces cells called megakaryocytes of the type seen in adults or of the sort found in infants.

This is important because the adult and infantile versions have very different specialties: Adult megakaryocytes are great at making platelets. Lots and lots of them. Infantile megakaryocytes, on the other hand, are much smaller cells, and they concentrate on dividing to produce more megakaryocytes.