IIT Mandy Discovers Molecular Mechanisms That Cause Fatty Liver Disease

Mandi, 15 June 2021:

This study by IIT Mandy shows that excessive sugar intake leads to fatty liver. This should provide an incentive for the public to reduce sugar intake in order to stop NAFLD in the early stages.

A team of researchers at IIT Mandy found the underlying biochemical relationship between excessive sugar consumption and the development of “fatty liver,” medically known as non-alcoholic fatty liver disease (NAFLD). Established.

This study will be conducted when the Government of India included NAFLD in the National Program for the Prevention and Management of Cancer, Diabetes, Cardiovascular Disease and Stroke (NPCDCS).

Dr. Prosenjit Mondal, an associate professor of basic science at IIT Mandy, described his work as follows: “The molecular mechanism by which excessive sugar intake increases liver DNL is unclear.

“Our goal was to elucidate this mechanical pathway between excessive sugar consumption and the onset and development of fatty liver through De Novo Lipogenesis (DNL).”

India is the first country in the world to justify the need for action against NAFLD. The prevalence of NAFLD in India is about 9% to 32% of the population, 49% in Kerala alone, and an astonishing 60% among obese school children. The prevalence.

One of the causes of NAFLD is an overdose of sugar (both table sugar (sucrose) and other forms of carbohydrates). Due to excessive sugar and carbohydrate consumption, the liver converts them into fat in a process called DNL in the liver, which accumulates fat.

Through a complementary experimental approach involving a mouse model, the IIT Mandi team demonstrated a previously unknown association between carbohydrate-induced activation of a protein complex called NF-κB and increased DNL. I did.

“Our data show that the hepatic NF-κBp65 sugar-mediated shuttle lowers levels of another protein, solcin, which activates hepatic DNL via a cascade biochemical pathway. Shows, “explained the chief scientist.

Elucidating the molecular link between sugar and fat accumulation in the liver is the key to developing a cure for this disease. The team has shown that drugs that can inhibit NF-κB can prevent sugar-induced liver fat accumulation. They also showed that knockdown of solcin reduces the lipid-lowering capacity of NF-κB inhibitors.

The IIT Mandy team’s discovery that NF-κB plays an important role in lipid accumulation in the liver opens new avenues for the treatment of NAFLD. NF-κB also plays a role in other inflammatory diseases such as cancer, Alzheimer’s disease, atherosclerosis, IBS, stroke, muscle wasting, and infections, and scientists around the world have called NF-κB. We are developing a treatment that can be blocked. Studies show that NAFLD can be added to the repertoire of diseases that can be treated with drugs that block NF-κB.

From a preventive point of view, studies have shown conclusively that excessive sugar intake leads to fatty liver. This should provide an incentive for the public to reduce sugar intake in order to stop NAFLD in the early stages.

The results of the team’s work were published in the Journal of Biological Chemistry. This research treatise was co-authored by Dr. Mondal and his researchers Vineeth Daniel, Surbhi Dogra, Priya Rawat, and IIT Mandi’s Abhinav Choubey, in collaboration with Dr. Mohan Kamthan and Aiysha Siddiq Khan of the Jamia Hamdard Institute in New Delhi. Sanjay Gandhi Post, Sanjay Gandhi Post, Sanjay Rajak, Institute of Medical Science (SGPGI), Lucknow.

IIT Mandy Discovers Molecular Mechanisms That Cause Fatty Liver Disease ET Health